Vomiting with Weight Loss

MANUAL OF CLINICAL DIAGNOSIS

Vomiting accompanied by weight loss is an alarming symptom that may indicate a serious underlying pathology. These symptoms suggest a disruption in the gastrointestinal system that impairs proper digestion and nutrient absorption.

A prompt and thorough evaluation is essential to determine the underlying cause and administer appropriate treatment, as significant weight loss can have severe consequences for the patient’s overall health.

Pathology	Clinical Symptoms and Signs	Suspected Diagnosis	Confirmatory Diagnosis
Oesophageal Disorders	Dysphagia, chest pain, regurgitation, vomiting, weight loss	Medical history, physical examination	Oesophageal endoscopy, oesophageal manometry, barium swallow
Oesophageal Carcinoma	Progressive dysphagia, odynophagia, chest pain, vomiting, weight loss, gastrointestinal bleeding	Medical history, physical examination	Endoscopy with biopsy, chest and abdominal computed tomography (CT)
Gastric Carcinoma	Dyspepsia, nausea, vomiting, early satiety, weight loss, epigastric pain	Medical history, physical examination	Endoscopy with biopsy, abdominal CT, blood tests
Small Intestine Tumour	Abdominal pain, vomiting, weight loss, gastrointestinal bleeding	Medical history, physical examination	Abdominal CT, capsule endoscopy, enteroscopy
Achalasia	Dysphagia for solids and liquids, nocturnal regurgitation, chest pain, weight loss	Medical history, physical examination	Oesophageal manometry, barium swallow, endoscopy